Edwards SJ, Lind T, Lundell L
Systematic review of proton pump inhibitors for the maintenance of healed reflux oesophagitis
J Outcomes Res 2002; 6: 1-14

The aim of the study was to compare the efficacy of lansoprazole with all other proton pump inhibitors in the maintenance of healed reflux oesophagitis through a systematic review of randomised controlled trials. A meta-analysis of patients in remission of reflux oesophagitis at 6 and 12 months was performed. The primary analysis used lansoprazole 15 mg as the common comparator. The results at 6 months were: esomeprazole 20 mg (Relative Risk 1.09; 95% Confidence Interval: 1.02, 1.17); lansoprazole 30 mg (RR 1.12; 95% CI: 1.06, 1.18); omeprazole 20 mg (RR 1.12; 95% CI: 1.06, 1.19). The results at 12 months were: lansoprazole 30 mg (RR 1.12; 95% CI: 1.05, 1.18); omeprazole 10 mg (RR 0.79; 95% CI: 0.64, 0.97); omeprazole 20 mg (RR 1.19; 95% CI: 1.10, 1.30).  Standard-dose PPIs are more efficacious than lansoprazole 15 mg in maintenance therapy. Esomeprazole 20 mg is the only step-down dose PPI able to show a significantly higher proportion of patients in remission of reflux oesophagitis when compared with lansoprazole 15 mg.

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