Content
Volume 7, 2003
Estimating the health utility of treatment in adults with growth hormone deficiency
S Dixon, P McEwan, CJ Currie, on behalf of the KIMS International Board
Pages 1-12 ¦ Abstract ¦
Self-reported dry eye symptoms in allergy patients using the disease impact questionnaire
M Alexander, J Walt, J Lee, C Burk
Pages 13-20 ¦
Impact of allergic conjunctivitis as measured by the Eye Allergy Patient Impact
Questionnaire (EAPIQ©)
D Lorenz, J Walt, J Lee, PM Buchholz, C Burk
Pages 21-33 ¦ Abstract ¦
Dixon S, McEwan P, Currie CJ, on behalf of the KIMS International Board
Estimating the health utility of treatment in adults with growth hormone deficiency
J Outcomes Res 2003; 7: 1-12
The detrimental effect of adult growth hormone deficiency on quality of life
is well described. Past studies have used several differing instruments to evaluate
quality of life. It has not been possible to capture all of the effects of treatment
within a single effectiveness measure such as health utility. This study used
regression techniques to derive utility figures for adults with growth hormone
deficiency.
Data from a previously published study were used to estimate an algorithm to
convert Nottingham Health Profile (NHP) responses into utility scores. This algorithm
was then applied to a treatment database of growth hormone deficient adults (KIMS).
Further work was undertaken to estimate utilities from a disease-specific measure.
Utility estimates were produced for a cohort of treated patients.
Three models were fitted with adjusted r-squared statistics between 55% and 65%.
Model coefficients were in line with expectation, although there were ceiling
effects in the estimated utilities. Treatment effects based on the estimated
utilities increased with worsening quality of life and were largely independent
of age. Model parameters are listed to map data from the Nottingham Health Profile
to utility scores, and data from the Adult Growth Hormone Deficiency Assessment
(AGHDA) to utility scores.
These analyses are a significant improvement on previous attempts to estimate
utilities from Nottingham Health Profile data. The estimated models generally
fitted these data well, they discriminated between different patient populations,
and they were sensitive to changes in quality of life associated with treatment.
Future research should use utility questionnaires in this patient group so that
the utility effects of treatment can be measured directly. In the meantime, the
utility estimates described here must be considered the best available data-source
for any cost-utility analysis for any treatment indicated for use in adults with
growth hormone deficiency.
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Lorenz D, Walt J, Lee J, Buchholz PM, Burk C
Impact of allergic conjunctivitis as measured by the Eye Allergy Patient Impact
Questionnaire (EAPIQ©)
J Outcomes Res 2003; 7: 21-33
This study assessed the impact of eye allergy symptoms in 124 allergic conjunctivitis
patients from four different ophthalmology clinics in the United States using
the Eye Allergy Patient Impact Questionnaire (EAPIQ©*). This questionnaire assessed
the impact of symptoms on patients’ function, emotions, and healthcare utilisation.
Mean age of patients was 47 years, 72% were female, 93% were white, and over 70%
spent the majority of waking hours indoors. More patients reported having ocular
symptoms (itchy, burning, and watery eyes) than being troubled by them, suggesting
tolerance to the symptoms. Compared to men, women were more frequently troubled
by how symptoms affected their
activities such as going outdoors (p<0.05). However, emotions, such as feeling
uncomfortable in social settings affected males more often than females (p<0.05).
Healthcare utilisation of females was higher than males. Eye allergy symptoms
affect many aspects of patients’ daily activities and their emotional state.
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